Aripiprazole CAS 129722-12-9 Purity >99.0% (HPLC) API

Short Description:

Chemical Name: Aripiprazole 

CAS: 129722-12-9

Purity: >99.0% (HPLC) 

Appearance: White or Almost White Crystalline Powder 

API High Quality, Commercial Production

E-Mail: alvin@ruifuchem.com


Product Detail

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Description:

Chemical Properties:

Chemical Name Aripiprazole 
Synonyms 7-[4-[4-(2,3-Dichlorophenyl)-1-Piperazinyl]butoxy]-3,4-Dihydro-2(1H)-Quinolinone
CAS Number 129722-12-9
CAT Number RF-PI2270
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C23H27Cl2N3O2
Molecular Weight 448.39  
Solubility Insoluble Soluble in Water; Insoluble in Methanol
Brand Ruifu Chemical

Specifications:

Item Specifications
Appearance White or Almost White Crystalline Powder
Identification By IR; By HPLC
Solubility Soluble in Acetic Acid, Slightly Soluble in Ethanol 
Melting Point 136.0~140.0℃
Loss on Drying <0.50%
Residue on Ignition <0.10%
Heavy Metals ≤20ppm
Residual Solvents
Ethanol ≤1000ppm
DMF ≤200ppm
Related Substances
Any Single Impurity <0.20%
Total Impurities <1.00%
Purity / Analysis Method >99.0% (HPLC) 
Assay       98.0%~102.0% (on the Anhydrous Basis)
Micro Limits
Total Aerobic Microbial Count ≤1000 cfu/g
Yeast and Mold Combined ≤100 cfu/g
E·Coli Absence
Pathogenic Organizing Absence
Test Standard Enterprise Standard
Usage API; Antipsychotic

Package & Storage:

Package: Bottle, 5kg/Aluminum tin, 25kg/Cardboard Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture

Advantages:

1

FAQ:

Application:

Aripiprazole (CAS: 129722-12-9) is a new kind of highly lipid soluble quinoline derivatives, its pharmacological effects characteristic is that it is not only the postsynaptic dopamine D2 receptor antagonist, but also the presynaptic dopamine D2 receptor agonist,it can also excite D1, D3, D4 receptors. Aripiprazole is a second generation atypical antipsychotic and anti-depressant with partial agonist activity at dopamine D2 and serotonin 5-HT1A receptors and antagonist activity at serotonin 5-HT2A receptors. Ki values are 0.34 nM, 0.8 nM, 1.7 nM, and 3.4 nM, respectively, for dopamine D2 and D3, serotonin 5-HT1A and 5-HT2A receptors. Aripiprazole is used for the treatment of schizophrenia and related psychotic disorders. Bristol-Myers Squibb and Otsuka Pharmaceutical Company announced that the European Union has approved Abilify (Aripiprazole) in the treatment of schizophrenia listing application. Schizophrenia affects 1% of the global population, and more in young adults. Schizophrenia affects thinking, emotional control and decision-making ability of the patient. Schizophrenia-positive patients will have symptoms such as hallucinations and delusions, patients with negative symptoms are social withdrawal, lack of emotional changes. In 2002 the FDA approved Abilify for the treatment of schizophrenia, which has five dosage strengths: 5 mg, 10 mg, 15 mg, 20 mg and 30 mg, since its approval.

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